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Be sure to tell them if any of the following factors apply to you: low vitamin B12 heart failure liver problems planned surgery upcoming imaging tests, such as an X-ray or CT scan kidney damage age 65 years or older hypoglycemia (low blood sugar) previous allergic reaction to Janumet or any of its ingredients pregnancy breastfeeding alcohol consumption Like most medications, Janumet and Janumet XR may cause mild or serious side effects

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It inhibits tyrosinase, a key enzyme involved in melanin production, and it also shifts melanin synthesis towards lighter pheomelanin rather than darker eumelanin, contributing to brighter-looking skin. Mechanism of action on pigmentation Melanin is the pigment responsible for skin colour, and its overproduction contributes to tanning, dark spots, and uneven tone